Rna Synthesis in Cultures of Normal Human Peripheral Blood.

T HERE HAS BEEN increasing acceptance of the concept that small lymphocytes can transform both in vitro and in vivo into larger cells capable of division.19 Repeated observation have shown that an increase in basophilic cytoplasm is an essential aspect of this transformation. Furthermore, electron microscopic studies of small lymphocytes growing in tissue culture have shown increase in ribosomal content in the transformed small lymphocytes.#{176} These observations suggested the present study of RNA synthesis during the transformation of small lymphocytes in tissue culture.